Validation study of the modified injection technique for internal mammary sentinel lymph node biopsy in breast cancer. full article pdf download

Title of article - Validation study of the modified injection technique for internal mammary sentinel lymph node biopsy in breast cancer.

Abstract

According to the hypothesis of internal mammary sentinel lymph node (IM-SLN) lymphatic drainage pattern, a modified radiotracer injection technique (periareolar intraparenchyma, high volume, and ultrasonographic guidance) was established. To verify the accuracy of the hypothesis and validate the modified radiotracer injection technique and to observe whether the lymphatic drainage of the whole breast parenchyma could reach to the same IM-SLN, different tracers were injected into different locations of the breast. The validation study results showed that the correlation and the agreement of the radiotracer and the fluorescence tracer are significant (case-base, r s =0.808, P<0.001; Kappa =0.79, P<0.001). It proved that the lymphatic drainage from different location of the breast (the primary tumor, the subareolar plexus) reached the same IM-SLNs and the hypothesis of IM-SLN lymphatic drainage pattern (ie, IM-SLN receives lymphatic drainage from not only the primary tumor area, but also the entire breast parenchyma). In other words, it validated the accuracy of our modified radiotracer injection technique.

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Breast Cancer Center, Shandong Cancer Hospital and Institute, Jinan University-Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China ; School of Medicine and Life Sciences, Jinan University-Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China.

Details of Journal for Validation study of the modified injection technique for internal mammary sentinel lymph node biopsy in breast cancer.

Journal Title - OncoTargets and therapy

ISSN - 1178-6930

Volume - 8

Issue - 0

Publish date - 2015-

Language - eng

Country - New Zealand