Title of article - Osteogenic programs during zebrafish fin regeneration.
Abstract
Recent advances in genomic, screening and imaging technologies have provided new opportunities to examine the molecular and cellular landscape underlying human physiology and disease. In the context of skeletal research, technologies for systems genetics, high-throughput screening and high-content imaging can aid an unbiased approach when searching for new biological, pathological or therapeutic pathways. However, these approaches necessitate the use of specialized model systems that rapidly produce a phenotype, are easy to manipulate, and amenable to optical study, all while representing mammalian bone physiologies at the molecular and cellular levels. The emerging use of zebrafish (Danio rerio) for modeling human disease highlights its potential to accelerate therapeutic and pathway discovery in the mammalian skeleton. In this review, we consider the potential value of zebrafish fin ray regeneration (a rapid, genetically tractable and optically transparent model of intramembranous ossification) as a translational model for such studies.
CLICK HERE for Full article Click button above to go to original article link with complete article details for Osteogenic programs during zebrafish fin regeneration.
Please CLICK HERE to discuss with us on facebook about this article.
Click below for Details of research Institute
Department of Orthopedics and Sports Medicine, University of Washington , Seattle, WA, USA.
Details of Journal for Osteogenic programs during zebrafish fin regeneration.
Journal Title - BoneKEy reports
ISSN - 2047-6396
Volume - 4
Issue - 0
Publish date - 2015-
Language - eng
Country - England
No comments:
Post a Comment