Title of article - Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action.
Abstract
In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action.
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Click below for Details of research Institute
Division of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, Italy.
Details of Journal for Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action.
Journal Title - International journal of endocrinology
ISSN - 1687-8337
Volume - 201
Issue - 0
Publish date - 2015-
Language - eng
Country - Egypt
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