Title of article - Using water-solvent systems to estimate in vivo blood-tissue partition coefficients.
Abstract
Blood-tissue partition coefficients indicate how a chemical will distribute throughout the body and are an important part of any pharmacokinetic study. They can be used to assess potential toxicological effects from exposure to chemicals and the efficacy of potential novel drugs designed to target certain organs or the central nervous system. In vivo measurement of blood-tissue partition coefficients is often complicated, time-consuming, and relatively expensive, so developing in vitro systems that approximate in vivo ones is desirable. We have determined such systems for tissues such as brain, muscle, liver, lung, kidney, heart, skin, and fat.
CLICK HERE for Full article Click button above to go to original article link with complete article details for Using water-solvent systems to estimate in vivo blood-tissue partition coefficients.
Please CLICK HERE to discuss with us on facebook about this article.
Click below for Details of research Institute
Computing and Mathematics Department, Oral Roberts University, Tulsa, OK 74171 USA.
Details of Journal for Using water-solvent systems to estimate in vivo blood-tissue partition coefficients.
Journal Title - Chemistry Central journal
ISSN - 1752-153X
Volume - 9
Issue - 0
Publish date - 2015-
Language - eng
Country - England
No comments:
Post a Comment