Title of article - To Investigate the Effect of Colchicine in Prevention of Adhesions Caused by Serosal Damage in Rats.
Abstract
Introduction and Aim. Adhesion formation is a process which starts with an inflammation caused by a number of factors and eventually results in fibrosis. Colchicine prevents adhesion formation which is antifibrous process. The effectivity of colchicine in the prevention of adhesions was investigated. Materials and Methods. A total of 36 rats were equally divided into three groups: (I) control group 1 (n = 12), (II) abrasion group 2 (n = 12), and (III) abrasion + colchicine group 3 (n = 12). Group 1 underwent laparotomy and was orally given physiological serum 2 cc/day for 10 days. In Group 2, injury was created in the cecum serosa following laparotomy and they were orally given physiological serum 2 cc/day for 10 days. In Group 3, injury was created in the cecum serosa following laparotomy and the rats were orally given colchicine 50 mcg kg/day mixed with physiological serum 2 cc/day for 10 days. Laparotomy was performed and adhesions were examined both macroscopically and microscopically. Both macroscopic and microscopic examinations were performed using Zühlke's score. Results. A significant difference was observed among the adhesion scores of the groups both macroscopically and microscopically. Macroscopic score was lower in group 3 than group 2. Microscopic score was lower in group 3 than group 2. Conclusion. Oral administration of colchicine is effective in the prevention of adhesions.
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Department of General Surgery, School of Medicine, Suleyman Demirel University, Isparta, Turkey.
Details of Journal for To Investigate the Effect of Colchicine in Prevention of Adhesions Caused by Serosal Damage in Rats.
Journal Title - Surgery research and practice
ISSN - 2356-7759
Volume - 201
Issue - 0
Publish date - 2015-
Language - eng
Country - United States
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