Title of article - Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Abstract
Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown. Here, we visualize how retroviruses disseminate in secondary lymphoid tissues of living mice. We demonstrate that murine leukemia virus (MLV) and human immunodeficiency virus (HIV) are first captured by sinus-lining macrophages. CD169/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus. MLV-laden macrophages then form long-lived synaptic contacts to trans-infect B-1 cells. Infected B-1 cells subsequently migrate into the lymph node to spread the infection through virological synapses. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread.
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Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Details of Journal for Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Journal Title - Science (New York, N.Y.)
ISSN - 1095-9203
Volume - 350
Issue - 6260
Publish date - 2015-Oct
Language - eng
Country - United States
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