Title of article - PHYSICS. Pumping up the quantum.
Abstract
There is growing interest in using engineered cells as therapeutic agents. For example, synthetic chimeric antigen receptors (CARs) can redirect T cells to recognize and eliminate tumor cells expressing specific antigens. Despite promising clinical results, these engineered T cells can exhibit excessive activity that is difficult to control and can cause severe toxicity. We designed "ON-switch" CARs that enable small-molecule control over T cell therapeutic functions while still retaining antigen specificity. In these split receptors, antigen-binding and intracellular signaling components assemble only in the presence of a heterodimerizing small molecule. This titratable pharmacologic regulation could allow physicians to precisely control the timing, location, and dosage of T cell activity, thereby mitigating toxicity. This work illustrates the potential of combining cellular engineering with orthogonal chemical tools to yield safer therapeutic cells that tightly integrate cell-autonomous recognition and user control.
CLICK HERE for Full article Click button above to go to original article link with complete article details for PHYSICS. Pumping up the quantum.
Please CLICK HERE to discuss with us on facebook about this article.
Click below for Details of research Institute
Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Details of Journal for PHYSICS. Pumping up the quantum.
Journal Title - Science (New York, N.Y.)
ISSN - 1095-9203
Volume - 350
Issue - 6258
Publish date - 2015-Oct
Language - eng
Country - United States
No comments:
Post a Comment