NON-RESPIRATORY FUNCTION OF THE LUNGS IN THE NIGROSTRIATAL DOPAMINERGIC SYSTEM DYSFUNCTION]. full article pdf download

Title of article - NON-RESPIRATORY FUNCTION OF THE LUNGS IN THE NIGROSTRIATAL DOPAMINERGIC SYSTEM DYSFUNCTION].

Abstract

The study presents a comprehensive of the metabolism and the fractional composition of li- pids surfactant, water balance, hemostatic activity of the lungs in neyrodegeneration substantia nigra of the brain induced by stereotaxic microinjection of 6--hydroxydopamine and systemic administration of haloperidol. It is shown that a breach of dopaminergic neurotransmission leads to deterioration of surface-active properties of the alveolar lining of the complex against a decrea- se of phospholipids, cholesterol, phosphatidylcholine and lysophospholipids enhance the pulmo- nary surfactant in the activation of phospholipase hydrolysis and lipid peroxidation. Intranigral introduction neurotoxin accompanied by increased blood supply to the lungs and the blood coagu- lation potential of the pulmonary circulation, the blockade D2-receptors--hyporhydration lung tissue. The results obtained indicate the formation of dysregulation pneumopathy dysfunction nigrostriatal dopaminergic system.

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Details of Journal for NON-RESPIRATORY FUNCTION OF THE LUNGS IN THE NIGROSTRIATAL DOPAMINERGIC SYSTEM DYSFUNCTION].

Journal Title - Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk

ISSN - 0869-8139

Volume - 101

Issue - 6

Publish date - 2015-Jun

Language - rus

Country - Russia (Federation)