Title of article - Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma.
Abstract
Adoptive T cell therapy (ACT) has shown great promise in melanoma, with over 50Â % response rate in patients where autologous tumor-reactive tumor-infiltrating lymphocytes (TIL) can be cultured and expanded. A major limitation of ACT is the inability to generate or expand autologous tumor-reactive TIL in 25-45Â % of patients tested. Methods that successfully identify tumors that are not suitable for TIL generation by standard methods would eliminate the costs of fruitless expansion and enable these patients to receive alternate therapy immediately.
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Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Providence Portland Medical Center, 4805 NE Glisan St, Portland, OR 97213 USA ; Departments of Cancer Biology, Oregon Health & Science University, Portland, OR USA.
Details of Journal for Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma.
Journal Title - Journal for immunotherapy of cancer
ISSN - 2051-1426
Volume - 3
Issue - 0
Publish date - 2015-
Language - eng
Country - England
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