Title of article - Interaction between circulating cancer cells and platelets: clinical implication.
Abstract
Metastasis is the main cause of cancer-associated mortality. During this complicated process, some cancer cells, also called circulating tumor cells (CTCs), detach from primary sites, enter bloodstream and extravasate at metastatic site. Thrombocytosis is frequently observed in patients with metastatic cancers suggesting the important role of platelets in metastasis. Therefore this review focuses on how platelets facilitate the generation of CTCs, protect them from various host attacks, such as immune assaults, apoptosis and shear stress, and regulate CTCs intravasation/extravasation. Platelet-derived cytokines and receptors are involved in this cascade. Identification the mechanisms underlie platelet-CTCs interactions could lead to the development of new platelet-targeted therapeutic strategy to reduce metastasis.
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1 Molecular Medicine and Genetics Center, 2 Department of Pathology, The Fourth Affiliated Hospital of Nanchang University, Nanchang 330000, China ; 3 Renmin Institute of Forensic Medicine, Nanchang 330000, China.
Details of Journal for Interaction between circulating cancer cells and platelets: clinical implication.
Journal Title - Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
ISSN - 1000-9604
Volume - 27
Issue - 5
Publish date - 2015-Oct
Language - eng
Country - China
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