Title of article - In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens.
Abstract
Amphipterygium adstringens is a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties. In this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of A. adstringens against oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Candida albicans, and Candida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines. Crude extract (CE) of A. adstringens showed some degree of activity against one or more of the strains with a MIC from 0.125 mg/mL to 63 mg/mL and MBC from 1.6 to 6.3 mg/mL and cytotoxic activity, particularly against NCI-ADR/RES, an ovarian cell line expressing multiple resistance drugs phenotype. The CE is a complex mixture of possible multitarget metabolites that could be responsible for both antimicrobial and antiproliferative activities, and further investigation is required to elucidate the identity of active compounds. Nevertheless the CE itself is useful in the development of new antimicrobial treatment based on natural products to prevent oral diseases and as alternative natural source for cancer treatment and prevention.
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Institute of Biotechnology, Faculty of Biological Sciences, Autonomous University of Nuevo Leon, Avenida Universidad S/N, Ciudad Universitaria, CP 66455, San Nicolas de los Garza, NL, Mexico.
Details of Journal for In Vitro Antimicrobial and Antiproliferative Activity of Amphipterygium adstringens.
Journal Title - Evidence-based complementary and alternative medicine : eCAM
ISSN - 1741-427X
Volume - 201
Issue - 0
Publish date - 2015-
Language - eng
Country - United States
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