Title of article - Huntington's disease is a multi-system disorder.
Abstract
Huntington's disease (HD) is one of the most common non-curable rare diseases and is characterized by choreic movements, psychiatric symptoms, and slowly progressive dementia. HD is inherited as an autosomal dominant disorder with complete penetrance. Although brain pathology has become a hallmark of HD, there is a critical mass of new studies suggesting peripheral tissue pathology as an important factor in disease progression. In particular, recently published studies about skeletal muscle malfunction and HD-related cardiomyopathy in HD mouse models strongly suggest their important roles, leading to upcoming preclinical and clinical trials. One might conclude that therapeutic approaches in HD should not be restricted only to the brain pathology but instead major efforts should also be made to understand the cross-talk between diseased tissues like the CNS-Heart or CNS-skeletal muscle axes.
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Department of Life Science; Imperial College London ; London, UK.
Details of Journal for Huntington's disease is a multi-system disorder.
Journal Title - Rare diseases (Austin, Tex.)
ISSN - 2167-5511
Volume - 3
Issue - 1
Publish date - 2015-
Language - eng
Country - United States
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