Title of article - Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy.
Abstract
The treatment of melanoma has been revolutionized by new therapies targeting MAPK signaling or the immune system. Unfortunately these therapies are hindered by either primary resistance or the development of acquired resistance. Resistance mechanisms involving somatic mutations in genes associated with resistance have been identified in some cases of melanoma, however, the cause of resistance remains largely unexplained in other cases. The importance of epigenetic factors targeting histones and histone modifiers in driving the behavior of melanoma is only starting to be unraveled and provides significant opportunity to combat the problems of therapy resistance. There is also an increasing ability to target these epigenetic changes with new drugs that inhibit these modifications to either prevent or overcome resistance to both MAPK inhibitors and immunotherapy. This review focuses on changes in histones, histone reader proteins and histone positioning, which can mediate resistance to new therapeutics and that can be targeted for future therapies.
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Melanoma Immunology and Oncology Group, Centenary Institute, University of Sydney, Camperdown 2050, Australia.
Details of Journal for Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy.
Journal Title - Cancers
ISSN - 2072-6694
Volume - 7
Issue - 4
Publish date - 2015-
Language - eng
Country - Switzerland
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