Gastrointestinal Tract Commensal Bacteria and Probiotics: Influence on End-Organ Physiology. full article pdf download

Title of article - Gastrointestinal Tract Commensal Bacteria and Probiotics: Influence on End-Organ Physiology.

Abstract

Bacteria represent the earliest form of independent life on this planet. Bacterial development has included cooperative symbiosis with plants (e.g., Leguminosae family and nitrogen fixing bacteria in soil) and animals (e.g., the gut microbiome). It is generally agreed upon that the fusion of two prokaryotes evolutionarily gave rise to the eukaryotic cell in which mitochondria may be envisaged as a genetically functional mosaic, a relic from one of the prokaryotes. This is expressed by the appearance of mitochondria in eukaryotic cells (an alpha-proteobacteria input), a significant endosymbiotic evolutionary event. As such, the evolution of human life has been complexly connected to bacterial activities. Hence, microbial colonization of mammals has been a progressively driven process. The interactions between the human host and the microbiome inhabiting the gastrointestinal tract (GIT) for example, afford the human host the necessary cues for the development of regulated signals that in part are induced by reactive oxygen species (ROS). This regulated activity then promotes immunological tolerance and metabolic regulation and stability, which then helps establish control of local and extraintestinal end-organ (e.g., kidneys) physiology. Pharmacobiotics, the targeted administration of live probiotic cultures, is an advancing area of potential therapeutics, either directly or as adjuvants. Hence the continued scientific understanding of the human microbiome in health and disease may further lead to fine tuning the targeted delivery of probiotics for a therapeutic gain.

CLICK HERE for Full article

Click button above to go to original article link with complete article details for Gastrointestinal Tract Commensal Bacteria and Probiotics: Influence on End-Organ Physiology.

Please CLICK HERE to discuss with us on facebook about this article.

Details of Journal for Gastrointestinal Tract Commensal Bacteria and Probiotics: Influence on End-Organ Physiology.

Journal Title - Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques

ISSN - 0071-786X

Volume - 70

Issue - 0

Publish date - 2015-

Language - eng

Country - Switzerland