Title of article - A new measure for the strength of electrical synapses.
Abstract
Electrical synapses, like chemical synapses, mediate intraneuronal communication. Electrical synapses are typically quantified by subthreshold measurements of coupling, which fall short in describing their impact on spiking activity in coupled neighbors. Here, we describe a novel measurement for electrical synapse strength that directly evaluates the effect of synaptically transmitted activity on spike timing. This method, also applicable to neurotransmitter-based synapses, communicates the considerable strength of electrical synapses. For electrical synapses measured in rodent slices of the thalamic reticular nucleus and in simple model neurons, spike timing is modulated by tens of ms by activity in a coupled neighbor.
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Department of Biological Sciences, Lehigh University Bethlehem, PA, USA.
Details of Journal for A new measure for the strength of electrical synapses.
Journal Title - Frontiers in cellular neuroscience
ISSN - 1662-5102
Volume - 9
Issue - 0
Publish date - 2015-
Language - eng
Country - Switzerland
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