New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties. full article pdf download

Title of article - New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties.

Abstract

The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra, and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 μM, respectively. Hexadecylguanidine (3) was not active against these receptors.

CLICK HERE for Full article

Click button above to go to original article link with complete article details for New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties.

Please CLICK HERE to discuss with us on facebook about this article.

Details of Journal for New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties.

Journal Title - Natural product communications

ISSN - 1934-578X

Volume - 10

Issue - 7

Publish date - 2015-Jul

Language - eng

Country - United States