BIOMEDICAL RESEARCH. Scripps hooks prominent pair to lead it to health. full article pdf download

Title of article - BIOMEDICAL RESEARCH. Scripps hooks prominent pair to lead it to health.

Abstract

The efficiency and selectivity of hydrogen atom transfer from organic molecules are often difficult to control in the presence of multiple potential hydrogen atom donors and acceptors. Here, we describe the mechanistic evaluation of a mode of catalytic activation that accomplishes the highly selective photoredox α-alkylation/lactonization of alcohols with methyl acrylate via a hydrogen atom transfer mechanism. Our studies indicate a particular role of tetra-n-butylammonium phosphate in enhancing the selectivity for α C-H bonds in alcohols in the presence of allylic, benzylic, α-C=O, and α-ether C-H bonds.

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Details of Journal for BIOMEDICAL RESEARCH. Scripps hooks prominent pair to lead it to health.

Journal Title - Science (New York, N.Y.)

ISSN - 1095-9203

Volume - 349

Issue - 6255

Publish date - 2015-Sep

Language - eng

Country - United States