Title of article - EFFECT OF INDOMETHACIN AND ITS COMPLEXES ON REPRODUCTIVE PERFORMANCE AND OXIDATIVE STRESS IN TESTIS AND STOMACH OF MALE ALBINO RATS WITH REFERENCE TO THEIR CHEMICAL CHARACTERIZATIONS.
Abstract
Four new complexes of Hg (II), Pb (II), Sn (II) and Bi (III) with indomethacin drug ligand (IMC) were synthesized and characterized by using infrared, electronic, 1H-NMR spectral, thermogravimetric and conductivity measurements. The IMC was found to act as bidentate chelating agent. IMC complexes coordinate through the oxygen of the carboxyl group. The molar ratio chelation is 1:2 (M2+:IMC) with general formula [M (IMC) 2], nH2O for Hg (II), Pb(II) and Sn(II), but 1:3 for Bi(III) ions. Antibacterial screening of these heavy metal complexes against Escherichia coli (Gram-ve), Bacillus subtilis (Gram +ve) and anti-fungi (Asperagillus oryzae, Asperagillus niger, Asperagillus Flavus) were investigated. In the present study, we found evidence suggesting that Bi+3/IMC possesses the capacity to protect the stomach, sperm, testes, cellular ATP, cellular NAD, INSL3, PGD2, PGE2 and antioxidant enzymes from deleterious actions of IMC.
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Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
Details of Journal for EFFECT OF INDOMETHACIN AND ITS COMPLEXES ON REPRODUCTIVE PERFORMANCE AND OXIDATIVE STRESS IN TESTIS AND STOMACH OF MALE ALBINO RATS WITH REFERENCE TO THEIR CHEMICAL CHARACTERIZATIONS.
Journal Title - Journal of biological regulators and homeostatic agents
ISSN - 0393-974X
Volume - 29
Issue - 3
Publish date - -
Language - eng
Country - Italy
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