Pharmaceutical history of capuchin monastery in Prague-Hradčan Part II. Capuchin balsam (Balsamum capucinorum)]. full article pdf download

Title of article - Pharmaceutical history of capuchin monastery in Prague-Hradčan Part II. Capuchin balsam (Balsamum capucinorum)].

Abstract

The history of traditional capuchin balsam is the focal point of the second part of the article on the unknown history of pharmacy at the capuchin monastery in Prague-Hradčany. Capuchin balsam, a medicinal speciality, was being manufactured in the monastery from the end of the 18th century till the year 1950. It is a spirit tincture, its prescription originating from the formulation by Oswald Croll. Balsamum Peruvianum, Gummiresina myrrha, Gummiresina olibanum, and Styrax are the main ingredients, besides assorted plants. The balsam was taken as an antiseptic, antiphlogistic, and analgesic. The balsam was a favoured rustic medicine, and it was sold also abroad (Germany, Poland, USA, Ireland, Belgium). The profit made from the sale of the balsam supported the reconstruction and the maintenance of the monastery and the local theological studies. Other medical formulations connected with the name of the capuchin order are also mentioned.Key words: pharmaceutical history capuchins capuchin balsam monastics pharmacies.

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Details of Journal for Pharmaceutical history of capuchin monastery in Prague-Hradčan Part II. Capuchin balsam (Balsamum capucinorum)].

Journal Title - Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti

ISSN - 1210-7816

Volume - 64

Issue - 3

Publish date - 2015-Jun

Language - cze

Country - Czech Republic

The Rapid Emergence of Novel Therapeutics in Advanced Malignant Melanoma. full article pdf download

Title of article - The Rapid Emergence of Novel Therapeutics in Advanced Malignant Melanoma.

Abstract

For decades, no cancer therapy had been shown to improve average survival in metastatic melanoma. Two critical events have occurred, the discovery of melanoma driver mutation subsets and the discovery of immune checkpoint inhibitors, which have allowed for the development of modern, effective therapies. These findings have facilitated a rapid emergence of novel therapeutics for the disease with multiple FDA approvals in the last several years. The drugs vemurafenib, trametinib, and dabrafenib, which inhibit the commonly mutated BRAF pathway, have been approved based on improvements in survival outcomes. Agents that block immune checkpoints on lymphocytes allowing for immune cell activity against melanoma have also been approved based on improved survival outcomes such as ipilimumab and nivolumab. Pembrolizumab, another immune checkpoint inhibitor, has also been approved based on the response rate and duration of response in a phase 1 trial. Further agents and combinations of approved agents are positioned to possibly further increase this tally of approved drugs. This review will discuss recently approved novel agents and select drugs in development in advanced melanoma.

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Baylor-Sammons Cancer Center, Texas Oncology, P.A., Dallas, TX, USA.

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Journal Title - Dermatology and therapy

ISSN - 2193-8210

Volume - 5

Issue - 3

Publish date - 2015-Sep

Language - eng

Country - Switzerland

The Effectiveness of Theory of Mind Training On the Social Skills of Children with High Functioning Autism Spectrum Disorders. full article pdf download

Title of article - The Effectiveness of Theory of Mind Training On the Social Skills of Children with High Functioning Autism Spectrum Disorders.

Abstract

Children with Autism Spectrum Disorders (ASD) tend to have problems in establishing and maintaining their social relationships. Some professionals believe this social impairment is the result of deficit in Theory of Mind (ToM). This study was conducted to explore the effectiveness of ToM training on such children.

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Department of Psychology and Education of Exceptional Children, Faculty of University of Social Welfare and rehabilitation Sciences, & pediatric Neurorehabilitation Research Center. Tehran, Iran.

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Journal Title - Iranian journal of child neurology

ISSN - 1735-4668

Volume - 9

Issue - 3

Publish date - 2015-

Language - eng

Country - Iran

How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression? full article pdf download

Title of article - How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?

Abstract

In this brief commentary, we have shown how the benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma from salivary gland can favor tumor progression, not only dying by autophagy/senescence phenomena, disrupting the physical barrier, but also providing fuel for tumor progression.

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Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira 13, Ponte Preta, 13045-755, Campinas, Brazil.

Details of Journal for How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?

Journal Title - Journal of cell communication and signaling

ISSN - 1873-9601

Volume - 9

Issue - 3

Publish date - 2015-Sep

Language - eng

Country - Netherlands

Acute and subchronic antihyperglycemic activities of Bowdichia virgilioides roots in non-diabetic and diabetic rats. full article pdf download

Title of article - Acute and subchronic antihyperglycemic activities of Bowdichia virgilioides roots in non-diabetic and diabetic rats.

Abstract

The present study was undertaken to evaluate the acute and subchronic antihyperglycemic effects of methanolic extract of Bowdichia virgilioides root bark of B. virgilioides in streptozotocin (STZ)-induced diabetic rats.

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Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.

Details of Journal for Acute and subchronic antihyperglycemic activities of Bowdichia virgilioides roots in non-diabetic and diabetic rats.

Journal Title - Journal of intercultural ethnopharmacology

ISSN - 2146-8397

Volume - 4

Issue - 1

Publish date - -

Language - eng

Country - Turkey

NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. full article pdf download

Title of article - NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage.

Abstract

The purpose of this study was to evaluate how increasing NaCl salinity in the medium can affects the essential oils (EOs) composition and phenolic diterpene content and yield in leaves of Salvia officinalis L. The protective role of such compounds against NaCl stress was also argued with regard to some physiological characteristics of the plant (water and ionic relations as well as the leaf gas exchanges).

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Laboratory of plant Ecophysiology, Centre for Environmental Research & Studies, Jazan University, Jazan, Kingdom of Saudi Arabia.

Details of Journal for NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage.

Journal Title - Journal of intercultural ethnopharmacology

ISSN - 2146-8397

Volume - 4

Issue - 3

Publish date - -

Language - eng

Country - Turkey

The effect of the use of a new type of partogram on the cesarean section rates. full article pdf download

Title of article - The effect of the use of a new type of partogram on the cesarean section rates.

Abstract

To assess the contribution of a new type of partogram, used in labor monitoring, in caesarean section rates.

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Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece.

Details of Journal for The effect of the use of a new type of partogram on the cesarean section rates.

Journal Title - Journal of the Turkish German Gynecological Association

ISSN - 1309-0399

Volume - 16

Issue - 3

Publish date - 2015-

Language - eng

Country - Turkey

A Candidate Dengue Vaccine Walks a Tightrope. full article pdf download

Title of article - A Candidate Dengue Vaccine Walks a Tightrope.

Abstract

A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in Asian-Pacific and Latin American countries. We report the results of long-term follow-up interim analyses and integrated efficacy analyses.

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From the Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

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Journal Title - The New England journal of medicine

ISSN - 1533-4406

Volume - 373

Issue - 13

Publish date - 2015-Sep

Language - eng

Country - United States

Advanced Dementia. full article pdf download

Title of article - Advanced Dementia.

Abstract

Like other human anatomical systems, the mammary ducts and glands at the time of lactation adhere to a perfect fractal geometry - which is destroyed by breast cancer. Could a loss of fractal geometry of the blood supply to human tissue be an early step in oncogenesis?

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Details of Journal for Advanced Dementia.

Journal Title - The New England journal of medicine

ISSN - 1533-4406

Volume - 373

Issue - 13

Publish date - 2015-Sep

Language - eng

Country - United States

Cannabis: 4 big questions. full article pdf download

Title of article - Cannabis: 4 big questions.

Abstract

The fisheries and livestock sectors capture the highest share of protein-rich animal food and demonstrate accelerated growth as an agriculture subsidiary. Environmental pollution, climate change, as well as pathogenic invasions exert increasing stress impacts that lead the productivity momentum at a crossroads. Oxidative stress is the most common form of stress phenomenon responsible for the retardation of productivity in fisheries and livestock. Essential micronutrients play a determinant role in combating oxidative stress. Selenium, one of the essential micronutrients, appears as a potent antioxidant with reduced toxicity in its nanoscale form. In the present review, different methods of synthesis and characterization of nanoscale selenium have been discussed. The functional characterization of nano-selenium in terms of its effect on growth patterns, feed digestibility, and reproductive system has been discussed to elucidate the mechanism of action. Moreover, its anti-carcinogenic and antioxidant potentiality, antimicrobial and immunomodulatory efficacy, and fatty acid reduction in liver have been deciphered as the new phenomena of nano-selenium application. Biologically synthesized nano-selenium raises hope for pharmacologically enriched, naturally stable nanoscale selenium with high ecological viability. Hence, nano-selenium can be administered with commercial feeds for improvising stress resilience and productivity of fish and livestock.

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NatureJobs in London.

Details of Journal for Cannabis: 4 big questions.

Journal Title - Nature

ISSN - 1476-4687

Volume - 525

Issue - 7570

Publish date - 2015-Sep

Language - eng

Country - England

Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm. full article pdf download

Title of article - Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm.

Abstract

Somaclonal variation arises in plants and animals when differentiated somatic cells are induced into a pluripotent state, but the resulting clones differ from each other and from their parents. In agriculture, somaclonal variation has hindered the micropropagation of elite hybrids and genetically modified crops, but the mechanism responsible remains unknown. The oil palm fruit 'mantled' abnormality is a somaclonal variant arising from tissue culture that drastically reduces yield, and has largely halted efforts to clone elite hybrids for oil production. Widely regarded as an epigenetic phenomenon, 'mantling' has defied explanation, but here we identify the MANTLED locus using epigenome-wide association studies of the African oil palm Elaeis guineensis. DNA hypomethylation of a LINE retrotransposon related to rice Karma, in the intron of the homeotic gene DEFICIENS, is common to all mantled clones and is associated with alternative splicing and premature termination. Dense methylation near the Karma splice site (termed the Good Karma epiallele) predicts normal fruit set, whereas hypomethylation (the Bad Karma epiallele) predicts homeotic transformation, parthenocarpy and marked loss of yield. Loss of Karma methylation and of small RNA in tissue culture contributes to the origin of mantled, while restoration in spontaneous revertants accounts for non-Mendelian inheritance. The ability to predict and cull mantling at the plantlet stage will facilitate the introduction of higher performing clones and optimize environmentally sensitive land resources.

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Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia.

Details of Journal for Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm.

Journal Title - Nature

ISSN - 1476-4687

Volume - 525

Issue - 7570

Publish date - 2015-Sep

Language - eng

Country - England

Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)]. full article pdf download

Title of article - Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)].

Abstract

Standardized uptake value (SUV) has been widely used as a semi-quantitative metric of uptake in FDGPET/ CT for diagnosis of malignant tumors and evaluation of tumor therapies. However, the SUV depends on various factors including PET/CT scanner specifications and reconstruction parameters. The purpose of this study is to harmonize the SUV among two PET/CT models of different generation: two units of Discovery ST Elite Performance(DSTEP) and Discovery 690 (D690) PET/CT scanners. The NEMA body phantom filled with 18F solution was scanned for 30 minutes in list-mode. The D690 PET images were reconstructed with OSEM, OSEM+TOF, and OSEM+PSF. Gaussian post-filters of 4-9 mm FWHM were applied to find the parameters that provides harmonized SUV. We determined the SUV-harmonized parameter for each reconstruction algorithm. Then, the 10 PET images simulating clinical scan conditions were respectively generated to evaluate the bias and variability of SUV(max) and SUV(peak). The SUV(max) strongly depended not only on spatial resolution but also on image noise. On the other hand, the SUV(peak) was a robust metric to image noise level. TOF improved the variability of SUV(max) and SUV(peak). Thus, we were able to harmonize the spatial resolution using SUV(peak) based on the phantom study. Because SUV(max) was also strongly affected by image noise, sufficient count statistics is essential for SUV(max) harmonization. We recommended that TOF reconstruction and SUV(peak) metric should be used to harmonize SUV.

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Department of Radiological Technology, Institute of Biomedical Research and Innovation.

Details of Journal for Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)].

Journal Title - Nihon Hōshasen Gijutsu Gakkai zasshi

ISSN - 0369-4305

Volume - 71

Issue - 9

Publish date - 2015-Sep

Language - jpn

Country - Japan

Dental peculiarities in the silvery mole-rat: an original model for studying the evolutionary and biological origins of continuous dental generation in mammals. full article pdf download

Title of article - Dental peculiarities in the silvery mole-rat: an original model for studying the evolutionary and biological origins of continuous dental generation in mammals.

Abstract

Unravelling the evolutionary and developmental mechanisms that have impacted the mammalian dentition, since more than 200 Ma, is an intricate issue. Interestingly, a few mammal species, including the silvery mole-rat Heliophobius argenteocinereus, are able to replace their dentition by the addition of supernumerary molars at the back of jaw migrating then toward the front. The aim here was to demonstrate the potential interest of further studying this rodent in order to better understand the origins of continuous dental replacement in mammals, which could also provide interesting data concerning the evolution of limited dental generation occurring in first mammals. In the present study, we described the main stages of the dental eruptive sequence in the silvery mole-rat and the associated characteristics of horizontal replacement using X-ray microtomography. This was coupled to the investigation of other African mole-rats which have no dental replacement. This method permitted to establish evidence that the initial development of the dentition in Heliophobius is comparable to what it is observed in most of African mole-rats. This rodent first has premolars, but then identical additional molars, a mechanism convergent to manatees and the pygmy rock-wallaby. Evidence of continuous replacement and strong dental dynamics were also illustrated in Heliophobius, and stressed the need to deeply investigate these aspects for evolutionary, functional and developmental purposes. We also noticed that two groups of extinct non-mammalian synapsids convergently acquired this dental mechanism, but in a way differing from extant mammals. The discussion on the diverse evolutionary origins of horizontal dental replacement put emphasis on the necessity of focusing on biological parameters potentially involved in both continuous and limited developments of teeth in mammals. In that context, the silvery mole-rat could appear as the most appropriate candidate to do so.

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Centre de Recherche sur la Paléobiodiversité et les Paléoenvironnements (CR2P), UMR CNRS 7207, Museum national d'Histoire naturelle, Université Paris 6 , Paris , France.

Details of Journal for Dental peculiarities in the silvery mole-rat: an original model for studying the evolutionary and biological origins of continuous dental generation in mammals.

Journal Title - PeerJ

ISSN - 2167-8359

Volume - 3

Issue - 0

Publish date - 2015-

Language - eng

Country - United States

Persistence of diet-induced obesity despite access to voluntary activity in mice lacking sarcolipin. full article pdf download

Title of article - Persistence of diet-induced obesity despite access to voluntary activity in mice lacking sarcolipin.

Abstract

Several rodent models of obesity have been shown to develop excessive adiposity only when voluntary cage ambulation is restricted. We have previously shown that mice lacking the sarco(endo)plasmic reticulum Ca(2+)-ATPase pump regulatory protein sarcolipin (Sln(-/-)), an uncoupler of Ca(2+) uptake, develop excessive diet-induced obesity under standard housing conditions. However, it is unclear whether this phenotype is due, in part, to the sedentary housing environment in which these animals are kept. To address this, we allowed wild-type and Sln(-/-) animals ad libitum access to voluntary wheel running while consuming a standard chow or high-fat diet for 8 weeks. During this period, wheel revolutions were monitored along with weekly mass gain. Postdiet glucose tolerance and visceral adiposity were also taken. The volume of wheel running completed was similar between genotype, regardless of diet. Although voluntary activity reduced mass gain relative to sedentary controls within each diet (P < 0.05), visceral adiposity was surprisingly unaltered with activity. However, Sln(-/-) mice developed excessive obesity (P < 0.05) and glucose intolerance (P < 0.05) with high-fat feeding relative to wild-type controls. These findings indicate that the excessive diet-induced obese phenotype previously observed in Sln(-/-) mice is not the result of severely restricted daily ambulation, but in fact the inability to recruit uncoupling of the Ca(2+)-ATPase pump.

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Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.

Details of Journal for Persistence of diet-induced obesity despite access to voluntary activity in mice lacking sarcolipin.

Journal Title - Physiological reports

ISSN - 2051-817X

Volume - 3

Issue - 9

Publish date - 2015-Sep

Language - eng

Country - United States

Reasons for the low bacteriological coverage of tuberculosis reported in Mpumalanga Province, South Africa. full article pdf download

Title of article - Reasons for the low bacteriological coverage of tuberculosis reported in Mpumalanga Province, South Africa.

Abstract

Public sector hospitals and primary health clinics in the Mpumalanga Province of South Africa.

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Mpumalanga Department of Health, Mpumalanga, South Africa.

Details of Journal for Reasons for the low bacteriological coverage of tuberculosis reported in Mpumalanga Province, South Africa.

Journal Title - Public health action

ISSN - 2220-8372

Volume - 5

Issue - 2

Publish date - 2015-Jun

Language - eng

Country - France

Prevalence and hospital discharge status of human immunodeficiency virus-associated pulmonary arterial hypertension in the United States. full article pdf download

Title of article - Prevalence and hospital discharge status of human immunodeficiency virus-associated pulmonary arterial hypertension in the United States.

Abstract

Pulmonary arterial hypertension (PAH) is a noninfectious complication of human immunodeficiency virus (HIV) infection that has gained in importance since the advent of antiretroviral therapy. HIV-associated PAH (HIV-PAH) has a higher prevalence than idiopathic PAH (IPAH), although the vascular pathology seen in HIV-PAH is virtually identical to that seen in IPAH. Initiating therapy for PAH at an early stage is associated with a better prognosis; however, because of the nonspecific symptoms associated with PAH, the diagnosis is often delayed. In addition, because of the low prevalence of HIV-PAH, routine screening for this condition has never been recommended. We hypothesize that the failure to create screening guidelines for HIV-PAH has resulted in underdiagnosis of the condition. This, in turn, results in individuals with HIV-PAH remaining undetected, allowing the disease to progress to more advanced stages or even remain unrecognized until death. If this hypothesis is correct, it may provide a strong argument for HIV-PAH screening guidelines, because HIV-PAH portends a poor prognosis and creates a significant economic burden if left untreated. To address this issue, we conducted a retrospective review of the National Hospital Discharge Survey data and the multiple-cause mortality data to determine the prevalence of HIV-PAH at hospital discharge and death. Using these large data sets, we observed that the prevalence of HIV-PAH among HIV-infected individuals at hospital discharge and death was significantly lower than the reported prevalence in the literature. In addition, we found that PAH was designated as the most common cause of mortality in patients with HIV-PAH.

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Department of Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA.

Details of Journal for Prevalence and hospital discharge status of human immunodeficiency virus-associated pulmonary arterial hypertension in the United States.

Journal Title - Pulmonary circulation

ISSN - 2045-8932

Volume - 5

Issue - 3

Publish date - 2015-Sep

Language - eng

Country - United States

Comparison of hybrid volumetric modulated arc therapy (VMAT) technique and double arc VMAT technique in the treatment of prostate cancer. full article pdf download

Title of article - Comparison of hybrid volumetric modulated arc therapy (VMAT) technique and double arc VMAT technique in the treatment of prostate cancer.

Abstract

Volumetric modulated arc therapy (VMAT) has quickly become accepted as standard of care for the treatment of prostate cancer based on studies showing it is able to provide faster delivery with adequate target coverage and reduced monitor units while maintaining organ at risk (OAR) sparing. This study aims to demonstrate the potential to increase dose conformality with increased planner control and OAR sparing using a hybrid treatment technique compared to VMAT.

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Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.

Details of Journal for Comparison of hybrid volumetric modulated arc therapy (VMAT) technique and double arc VMAT technique in the treatment of prostate cancer.

Journal Title - Radiology and oncology

ISSN - 1318-2099

Volume - 49

Issue - 3

Publish date - 2015-Sep

Language - eng

Country - Slovenia

Sequential invasive-noninvasive mechanical ventilation weaning strategy for patients after tracheostomy. full article pdf download

Title of article - Sequential invasive-noninvasive mechanical ventilation weaning strategy for patients after tracheostomy.

Abstract

Because the continuity and integrity of the trachea are likely damaged to some extent after tracheostomy, the implementation of sequential ventilation has certain difficulties, and sequential invasive-noninvasive ventilation on patients after tracheostomy is less common in practice. The present study aimed to investigate the feasibility of invasive-noninvasive sequential weaning strategy in patients after tracheostomy.

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Department of Geriatric Pulmonary Diseases, Anhui Geriatric Institute, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

Details of Journal for Sequential invasive-noninvasive mechanical ventilation weaning strategy for patients after tracheostomy.

Journal Title - World journal of emergency medicine

ISSN - 1920-8642

Volume - 6

Issue - 3

Publish date - 2015-

Language - eng

Country - China

Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”. full article pdf download

Title of article - Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”.

Abstract

The incidence of malignant melanoma, a cancer of the melanocyte cell lineage, has nearly doubled in the past 20 years. Wnt5A, akey driver of melanoma invasiveness, induces Ca2 signals. To understand how store-operated calcium entry (SOCE) contributes to Wnt5A-induced malignancy in melanoma models, we examined the expression and function of STIM1 and Orai1 in patient-derived malignant melanoma cells, previously characterized as either highly invasive (metastatic) or noninvasive. Using both fluorescence microscopy and electrophysiological approaches, we show that SOCE is greatly diminished in invasive melanoma compared to its level in noninvasive cell types. However, no loss of expression of any members of the STIM and Orai families was observed in invasive melanoma cells. Moreover, overexpressed wild-type STIM1 and Orai1 failed to restore SOCE in invasive melanoma cells, and we observed no defects in their localization before or after store depletion in any of the invasive celllines. Importantly, however, we determined that SOCE was restored by inhibition of protein kinase C, a known downstream target of Wnt5A. Furthermore, coexpression of STIM1 with an Orai1 mutant insensitive to protein kinase C-mediated phosphorylation fully restored SOCE in invasive melanoma. These findings reveal a level of control for STIM/Orai function in invasive melanoma not previously reported.

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Details of Journal for Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”.

Journal Title - Circulation. Heart failure

ISSN - 1941-3297

Volume - 8

Issue - 4

Publish date - 2015-Jul

Language - eng

Country - United States

Effect of a new low-cholesterol meat and vegetal product on correction of simulated lipid metabolism disorders in rats]. full article pdf download

Title of article - Effect of a new low-cholesterol meat and vegetal product on correction of simulated lipid metabolism disorders in rats].

Abstract

The paper presents the biomedical evaluation of meat and cereal spread from low-cholesterol raw material with vegetable ingredients, recommended as a functional food. The experimental model with myocardial infarction like changes in hearts of the animals, accompanied by vascular changes similar to atherosclerotic changes in humans, as well as the modeling of the metabolic imbalance of lipids have been carried out by intramuscular injection of epinephrine and unbalanced feeding the animals with food rich in cholesterol, with a high content of carbohydrates and fats. Wistar rats were divided into 4 groups of 12 animals each. The rats in groups 1-3 were induced the cardio distress with intramuscular injection of epinephrine; group IV consisted of intact (healthy) animals. Dramatic changes in biochemical blood status that indicated heart disease have been observed within 2 days after the injection of epinephrine (0.2 ml per 1 kg of animal body weight) to the tested animals. During the experiment a sharp increase in activity of indicator enzymes of alanine aminotransferase (ALT) and aspartate aminotransferases (AST), with a predominance of AST over ALT, along with an increase in LDH activity have been observed. The 1.4-1.6 fold increase in blood serum creatinine has also been found. Later the animals in groups 1, 2, 3 with simulated cardio pathology were fed a ration with intervention of food rich in cholesterol, with a high content of carbohydrates and fats (50% of the diet) for a month for induction of lipid metabolism disorders. An increase in the concentration of cholesterol and triglycerides by 3 fold or more has been observed. In addition, an accumulation of sulfhydryl groups has been noted, as evidenced by increased rates of thymol. For further normalization of lipid metabolism, the animals in tested group I were fed the diet with intervention of spread, developed in accordance with GOST 12318-91 "Canned meat "Meat spread"; the rats of group 2 were fed with spread with vegetable supplements (pumpkin by-products and alginates), and group 3 received a standard diet within the next month. The results of biochemical blood serum studies have shown that the level of cholesterol, triglycerides, creatinine and sulphydryl groups in the experimental groups 1 and 2 decreased, indicating a positive influence on lipid metabolism and prevention of peroxides formation in the organism. These changes were more pronounced when meat product with plant additives and alginate was used in the diet. Only under the application of the meat-vegetable pate cholesterol level ceased to differ from that of the control group of animals. Based on the significant reduction of blood malondialdehyde level, antioxidant properties of vegetable supplements have been proven. The experimental data showed that the spread, developed on the basis of low-cholesterol raw meat with vegetable ingredients (pumpkin by-products and alginates) can be used to correct metabolic disorders of lipids, reducing the risk of cardio pathology in the body.

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Journal Title - Voprosy pitaniia

ISSN - 0042-8833

Volume - 84

Issue - 1

Publish date - 2015-

Language - rus

Country - Russia (Federation)

Fine-root responses to fertilization reveal multiple nutrient limitation in a lowland tropical forest. full article pdf download

Title of article - Fine-root responses to fertilization reveal multiple nutrient limitation in a lowland tropical forest.

Abstract

Questions remain as to which soil nutrients limit primary production in tropical forests. Phosphorus (P) has long been considered the primary limiting element in lowland forests, but recent evidence demonstrates substantial heterogeneity in response to nutrient addition, highlighting a need to understand and diagnose nutrient limitation across diverse forests. Fine-root characteristics including their abundance, functional traits, and mycorrhizal symbionts can be highly responsive to changes in soil nutrients and may help to diagnose nutrient limitation. Here, we document the response of fine roots to long-term nitrogen (N), P, and potassium (K) fertilization in a lowland forest in Panama. Because this experiment has demonstrated that N and K together limit tree growth and P limits fine litter production, we hypothesized that fine roots would also respond to nutrient addition. Specifically we hypothesized that N, P, and K addition would reduce the biomass, diameter, tissue density, and mycorrhizal colonization of fine roots, and increase nutrient concentration in root tissue. Most morphological root traits responded to the single addition of K and the paired addition of N and P, with the greatest response to all three nutrients combined. The addition of N, P, and K together reduced fine-root biomass, length, and tissue density, and increased specific root length, whereas root diameter remained unchanged. Nitrogen addition did not alter root N concentration, but P and K addition increased root P and K concentration, respectively. Mycorrhizal colonization of fine roots declined with N, increased with P, and was unresponsive to K addition. Although plant species composition remains unchanged after 14 years of fertilization, fine-root characteristics responded to N, P, and K addition, providing some of the strongest stand-level responses in this experiment. Multiple soil nutrients regulate fine-root abundance, morphological and chemical traits, and their association with mycorrhizal fungi in a species-rich lowland tropical forest.

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Journal Title - Ecology

ISSN - 0012-9658

Volume - 96

Issue - 8

Publish date - 2015-Aug

Language - eng

Country - United States

Efficacy of long-term low-dose sulodexide in diabetic and non-diabetic nephropathies. full article pdf download

Title of article - Efficacy of long-term low-dose sulodexide in diabetic and non-diabetic nephropathies.

Abstract

Sulodexide has been reported to have antiproteinuric and nephroprotective properties. We investigated the effects of long-term low-dose Sulodexide on proteinuria and renal function in patients with chronic kidney disease (CKD) caused by diabetic nephropathy (DN), hypertensive nephropathy (HN) and primary glomerulonephritis (GN).

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Journal Title - Romanian journal of internal medicine = Revue roumaine de médecine interne

ISSN - 1220-4749

Volume - 53

Issue - 2

Publish date - -

Language - eng

Country - Romania

Avoiding the 'iHunch'. full article pdf download

Title of article - Avoiding the 'iHunch'.

Abstract

A systematic appraisal of evidence suggests that male patients in hospital may be at higher risk for bacteremia following urinary catheter-associated bacteriuria than females. Other risk factors include immunosuppressant medication, red blood cell transfusion, neutropenia, malignancy, and liver disease.

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Journal Title - Nursing New Zealand (Wellington, N.Z. : 1995)

ISSN - 1173-2032

Volume - 21

Issue - 6

Publish date - 2015-Jul

Language - eng

Country - New Zealand

Reducing pain at the time of vaccination: WHO position paper - September 2015. full article pdf download

Title of article - Reducing pain at the time of vaccination: WHO position paper - September 2015.

Abstract

It was not Dutch settlers nor British colonizers who introduced public and community health practice in north-eastern South Africa but medical doctors of the Swiss mission in southern Africa. While the history of medical knowledge transfer into 19th-20th century Africa emphasises colonial powers, this paper shows how countries without colonies contributed to expand western medical cultures, including public health. The Swiss took advantage of the local authorities' negligence, and implemented their own model of medicalization of African societies, understood as the way of improving health standards. They moved from a tolerated hospital-centred medicine to the practice of community health, which was uncommon at the time. Elim hospital's physicians moved back boundaries of segregationist policies, and sometime gave the impression of being involved in the political struggle against Apartheid. Thus, Swiss public health activities could later be seen as sorts of seeds that were planted and would partly reappear in 1994 with the ANC-projected national health policy.

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Journal Title - Relevé épidémiologique hebdomadaire / Section d'hygiène du Secrétariat de la Société des Nations = Weekly epidemiological record / Health Section of the Secretariat of the League of Nations

ISSN - 0049-8114

Volume - 90

Issue - 39

Publish date - 2015-Sep

Language - eng

Country - Switzerland

DAPPER: a data-mining resource for protein-protein interactions. full article pdf download

Title of article - DAPPER: a data-mining resource for protein-protein interactions.

Abstract

The identification of interaction networks between proteins and complexes holds the promise of offering novel insights into the molecular mechanisms that regulate many biological processes. With increasing volumes of such datasets, especially in model organisms such as Drosophila melanogaster, there exists a pressing need for specialised tools, which can seamlessly collect, integrate and analyse these data. Here we describe a database coupled with a mining tool for protein-protein interactions (DAPPER), developed as a rich resource for studying multi-protein complexes in Drosophila melanogaster.

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Computer Laboratory, University of Cambridge, Cambridge, CB3 0FD UK.

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Journal Title - BioData mining

ISSN - 1756-0381

Volume - 8

Issue - 0

Publish date - 2015-

Language - eng

Country - England

Isolation and characterization of bacteriocinogenic lactic bacteria from M-Tuba and Tepache, two traditional fermented beverages in México. full article pdf download

Title of article - Isolation and characterization of bacteriocinogenic lactic bacteria from M-Tuba and Tepache, two traditional fermented beverages in México.

Abstract

Mexican Tuba (M-Tuba) and Tepache are Mexican fermented beverages prepared mainly with pineapple pulp and coconut palm, respectively. At present, reports on the microbiota and nutritional effects of both beverages are lacking. The purpose of this study was to determine whether M-Tuba and Tepache contain cultivable lactic acid bacteria (LAB) capable of producing bacteriocins. Tepache and M-Tuba contain mesophilic aerobic bacteria, LAB, and yeast. Bacillus subtilis, Listeria monocytogenes, Listeria innocua, Streptococcus agalactiae, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, and Salmonella spp, were the microorganisms most susceptible to metabolites produced by bacterial isolates. M-Tuba and Tepache contain bacteria that harbor genes coding for nisin and enterocin, but not pediocin. The presence of Lactococcus lactis and E. faecium in M-Tuba and Tepache, was identified by 16S rDNA. These bacteria produced bacteriocins of ∼3.5 kDa and 4.0-4.5 kDa, respectively. Partial purified bacteriocins showed inhibitory effect against Micrococcus luteus, L. monocytogenes, L. innocua, Str. agalactiae, S. aureus, Bacillus cereus, B. subtilis, E. faecalis, and K. pneumoniae. We characterized, for the first time, cultivable microbiota of M-Tuba and Tepache, and specifically, identified candidate lactic bacteria (LAB) present in these beverages that were capable of synthesizing antimicrobial peptides, which collectively could provide food preservative functions.

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Escuela de Ciencias Biológicas, Universidad Autónoma de Coahuila, Ciudad Universitaria Campus Torreón Torreón Coah, Coahuila, CP 27104, México.

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Journal Title - Food science & nutrition

ISSN - 2048-7177

Volume - 3

Issue - 5

Publish date - 2015-Sep

Language - eng

Country - United States

Draft Genome Sequence of the Gram-Positive Thermophilic Iron Reducer Thermincola ferriacetica Strain Z-0001T. full article pdf download

Title of article - Draft Genome Sequence of the Gram-Positive Thermophilic Iron Reducer Thermincola ferriacetica Strain Z-0001T.

Abstract

A 3.19-Mbp draft genome of the Gram-positive thermophilic iron-reducing Firmicutes isolate from the Peptococcaceae family, Thermincola ferriacetica Z-0001, was assembled at ~100× coverage from 100-bp paired-end Illumina reads. The draft genome contains 3,274 predicted genes (3,187 protein coding genes) and putative multiheme c-type cytochromes.

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Swette Center for Environmental Biotechnology, The Biodesign Institute at Arizona State University, Tempe, Arizona, USA

Details of Journal for Draft Genome Sequence of the Gram-Positive Thermophilic Iron Reducer Thermincola ferriacetica Strain Z-0001T.

Journal Title - Genome announcements

ISSN - 2169-8287

Volume - 3

Issue - 5

Publish date - 2015-

Language - eng

Country - United States

Retrospective Review of Critically Ill Patients Experiencing Alcohol Withdrawal: Dexmedetomidine Versus Propofol and/or Lorazepam Continuous Infusions. full article pdf download

Title of article - Retrospective Review of Critically Ill Patients Experiencing Alcohol Withdrawal: Dexmedetomidine Versus Propofol and/or Lorazepam Continuous Infusions.

Abstract

Alcohol withdrawal symptoms can be difficult to manage and may lead to an intensive care unit (ICU) admission. Patients experiencing severe alcohol withdrawal often require high doses of sedatives, which can lead to respiratory depression and the need for endotracheal intubation. Dexmedetomidine, an alpha-2 adrenoreceptor agonist, provides adequate sedation with little effect on respiratory function when compared to other sedatives.

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Pharmacist, North Colorado Medical Center , Greeley, Colorado.

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Journal Title - Hospital pharmacy

ISSN - 0018-5787

Volume - 50

Issue - 3

Publish date - 2015-Mar

Language - eng

Country - United States

Bacteremia in Preterm Infants Receiving Probiotics; Throbbing Headache Associated with Enoxaparin Use; DRESS Reaction Following Isoniazid Treatment; SIADH Associated with Glimepiride; Mania Associated with Bortezomib Administration. full article pdf download

Title of article - Bacteremia in Preterm Infants Receiving Probiotics; Throbbing Headache Associated with Enoxaparin Use; DRESS Reaction Following Isoniazid Treatment; SIADH Associated with Glimepiride; Mania Associated with Bortezomib Administration.

Abstract

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in cooperation with the FDA's MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch partner.

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Chair and Clinical Professor, Department of Pharmacy Practice, Temple University School of Pharmacy , Philadelphia, Pennsylvania ; Clinical Advisor, Institute for Safe Medication Practices , Horsham, Pennsylvania.

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Journal Title - Hospital pharmacy

ISSN - 0018-5787

Volume - 50

Issue - 6

Publish date - 2015-Jun

Language - eng

Country - United States

Ultrathin Silicon Sheet in the Management of Unilateral Post-traumatic Temporo-Mandibuar Joint Ankylosis in Children: A Good Alternative to Conventional Techniques. full article pdf download

Title of article - Ultrathin Silicon Sheet in the Management of Unilateral Post-traumatic Temporo-Mandibuar Joint Ankylosis in Children: A Good Alternative to Conventional Techniques.

Abstract

We have described a new technique of using ultra-thin silicon sheet (0.2 mm) between two transected bony ends for temporo-mandibular joint (TMJ) ankylosis in children with advantages of short operative time, minimal foreign material insertion and faster recovery time post-operatively which makes our technique a good alternative to conventional techniques. Our study is a non-randomized prospective study conducted on 10 children aged between 4 and 15 years who presented to our tertiary care institute with severe trismus after traumatic injury and were willing to undergo this new technique. The main outcome measure taken into consideration was difference between pre-operative, intra-operative (on table) and post-operative mouth opening (minimum 2 years follow-up). The pre-operative mouth opening in our cases varied from 1 to 5 mm. The intra-operative mouth opening achieved ranged from 2.8 to 3.2 cm. The mouth opening was about more than 2.7 cm in all our cases at 2 years of follow-up. Our technique is a good alternative to conventional techniques used for TMJ ankylosis in children but few more randomized controlled trials are required to assess its effectiveness in comparison to conventional techniques and for universal adoption of this technique.

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Department of ENT, IMS, BHU, Varanasi, 221005 India.

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Journal Title - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

ISSN - 2231-3796

Volume - 67

Issue - 3

Publish date - 2015-Sep

Language - eng

Country - India

Gastric Schwannoma: A Case Report and Review of Literature. full article pdf download

Title of article - Gastric Schwannoma: A Case Report and Review of Literature.

Abstract

Schwannomas are usually benign, slow growing tumors, that originate from any nerve that has a Schwann cell sheath. Here, we report the case of a 40 year-old female patient with an incidentally noted submucosal gastric tumor while being evaluated for cervical lymphadenopathy as a part of workup for lymphoma. She underwent sleeve resection of the stomach under suspicion of a gastrointestinal stromal tumor, but postoperative histopathological and immunohistochemical findings confirmed the diagnosis of shwannoma. Although schwannomas are mostly benign, they are often indistinguishable preoperatively from malignant tumors such as gastrointestinal stromal tumors. Therefore, resection is the treatment of choice for all such tumors.

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Department of General Surgery, M.S. Ramaiah Medical College and Hospitals, M.S.R.I.T Post, M.S.R. Nagar, Bangalore, 560054 Karnataka India.

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Journal Title - Indian journal of surgical oncology

ISSN - 0975-7651

Volume - 6

Issue - 2

Publish date - 2015-Jun

Language - eng

Country - India

EFFECT OF INDOMETHACIN AND ITS COMPLEXES ON REPRODUCTIVE PERFORMANCE AND OXIDATIVE STRESS IN TESTIS AND STOMACH OF MALE ALBINO RATS WITH REFERENCE TO THEIR CHEMICAL CHARACTERIZATIONS. full article pdf download

Title of article - EFFECT OF INDOMETHACIN AND ITS COMPLEXES ON REPRODUCTIVE PERFORMANCE AND OXIDATIVE STRESS IN TESTIS AND STOMACH OF MALE ALBINO RATS WITH REFERENCE TO THEIR CHEMICAL CHARACTERIZATIONS.

Abstract

Four new complexes of Hg (II), Pb (II), Sn (II) and Bi (III) with indomethacin drug ligand (IMC) were synthesized and characterized by using infrared, electronic, 1H-NMR spectral, thermogravimetric and conductivity measurements. The IMC was found to act as bidentate chelating agent. IMC complexes coordinate through the oxygen of the carboxyl group. The molar ratio chelation is 1:2 (M2+:IMC) with general formula [M (IMC) 2], nH2O for Hg (II), Pb(II) and Sn(II), but 1:3 for Bi(III) ions. Antibacterial screening of these heavy metal complexes against Escherichia coli (Gram-ve), Bacillus subtilis (Gram +ve) and anti-fungi (Asperagillus oryzae, Asperagillus niger, Asperagillus Flavus) were investigated. In the present study, we found evidence suggesting that Bi+3/IMC possesses the capacity to protect the stomach, sperm, testes, cellular ATP, cellular NAD, INSL3, PGD2, PGE2 and antioxidant enzymes from deleterious actions of IMC.

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Department of Chemistry, Faculty of Science, Taif University, Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

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Journal Title - Journal of biological regulators and homeostatic agents

ISSN - 0393-974X

Volume - 29

Issue - 3

Publish date - -

Language - eng

Country - Italy